QuickView for centromere protein A;jsessionid=164C5AA22309A4C7FB54489A9C754BB3;jsessionid=640959CDED63FC8EA14CDE7F00436E04;jsessionid=FC45B759F85F2D56CC1787791960572A (gene)

Gene Symbol:

Cenpa Mus musculus

Full name:

centromere protein A

Synonyms:

Cenp-A, histone H3-like centromeric protein A, centromere autoantigen A, centrosomin A

Genomic Location:

Chr 5: 30969275-30977199

Description:

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like struc...

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Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

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